Downregulation and pro-apoptotic effect of hypoxia-inducible factor 2 alpha in hepatocellular carcinoma
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摘要The role of HIF-2a in hepatocellular carcinoma (HCC) is unclear. The aim of the present study was to investigate the expression pattern and role of HIF-2a in HCC patients. Immunohistochemical staining and western blotting analyses were applied to detect the protein level of HIF-2a in 206 paired HCC and peritumoral tissues. Kaplan-Meier survival and Cox proportional hazard regression analyses were performed to identify risk factors for overall survival and recurrence-free survival in these patients. The function of HIF-2a was studied in HCC cells and in vivo models. We found that the protein levels of HIF-2a in HCC tissues were lower than in peritumoral tissues, and were negatively correlated with tumor size (P < 0.05). Kaplan-Meier survival and univariate analysis revealed that HCC patients with high HIF-2a protein levels had longer overall survival (P < 0.05). Over-expression of HIF-2a induced apoptosis in HCC cells and increased the levels of pro-apoptotic proteins, Bak, ZBP-89 and PDCD4, whereas the inhibition of HIF-2a expression achieved opposite results. The findings were confirmed in a mouse HCC xenograft model. In conclusion, our study revealed that HIF-2a was decreased and played an anti-tumorigenic role in HCC.
著者Yang SL, Liu LP, Niu L, Sun YF, Yang XR, Fan J, Ren JW, Chen GG, Lai PBS
期刊名稱Oncotarget
出版年份2016
月份6
日期7
卷號7
期次23
出版社IMPACT JOURNALS LLC
頁次34571 - 34581
國際標準期刊號1949-2553
語言英式英語
關鍵詞apoptosis; hepatocellular carcinoma; HIF-2 alpha; overall survival; prognosis
Web of Science 學科類別Cell Biology; Oncology

上次更新時間 2020-27-11 於 01:53