Comprehensive characterization of the patient-derived xenograft and the paralleled primary hepatocellular carcinoma cell line
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AbstractBackground: Hepatocellular carcinoma (HCC) is an aggressive cancer with high mortality and morbidity worldwide. The limited clinically relevant model has impeded the development of effective HCC treatment strategy. Patient-derived xenograft (PDX) models retain most of the characteristics of original tumors and were shown to be highly predictive for clinical outcomes. Notably, primary cell line models allow in-depth molecular characterization and high-throughput analysis. Combined usage of the two models would provide an excellent tool for systematic study of therapeutic strategies. Here, we comprehensively characterized the novel PDX and the paralleled primary HCC cell line model.
All Author(s) ListCheung PFY, Yip CW, Ng LWC, Lo KW, Chow C, Chan KF, Cheung TT, Cheung ST
Journal nameCancer Cell International
Volume Number16
LanguagesEnglish-United Kingdom
KeywordsCell line establishment; Hepatocellular carcinoma; Patient-derived xenograft
Web of Science Subject CategoriesOncology

Last updated on 2020-25-09 at 00:46