Plasma miR-124-3p and miR-16 concentrations as prognostic markers in acute stroke
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AbstractObjectives: This study aimed to investigate plasma concentrations of miR-124-3p and miR-16 as prognostic markers in emergency department patients with acute stroke.Design and methods: Plasma concentrations of miR-124-3p and miR-16 of 84 stroke patients (presenting to the emergency department within 24 h from onset of symptoms) were determined by RT-qPCR. The primary outcome measure was 3-month mortality and the secondary outcome measure was post-stroke modified Rankin Score (mRS).Results: Twelve patients (14.3%) died within 3 months of hospital admission and forty-one (48.8%) patients as achieved a 3-month mRS > 2. Median plasma miR-124-3p concentrations were elevated in patients who died compared to patients who survived (p = 0.0052), and its levels were found to be higher in patients with a 3-month mRS <= 2 compared with patients with mRS = 2 (p = 0.0312). Higher plasma miR-16 concentrations were observed in patients who survived than in patients who died (p = 0.0394), while its concentrations were lower in patients achieving mRS N 2 than in patients with mRS = 2 (p = 0.0124). For a subgroup of cases presenting to the emergency department within 6 h from time of symptom onset (n = 36), plasma miR-1243p concentrations predicted 3-month mortality with an area under the ROC curve of 0.87 (95% CI: 0.72-0.96).Conclusions: Plasma miR-124-3p and miR-16 are molecular markers which could be useful for the early prediction of mortality and mRS. (C) 2016 The Canadian Society of Clinical Chemists.
All Author(s) ListRainer TH, Leung LY, Chan CPY, Leung YK, Abrigo JM, Wang DF, Graham CA
Journal nameClinical Biochemistry
Year2016
Month6
Day1
Volume Number49
Issue Number9
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Pages663 - 668
ISSN0009-9120
eISSN1873-2933
LanguagesEnglish-United Kingdom
KeywordsmicroRNA; Plasma; Prognosis; Stroke
Web of Science Subject CategoriesMedical Laboratory Technology

Last updated on 2020-08-08 at 00:53