Discovery and functional characterization of novel miRNAs in the marine medaka Oryzias melastigma
Publication in refereed journal


Times Cited
Web of Science3WOS source URL (as at 02/08/2020) Click here for the latest count
Altmetrics Information
.

Other information
AbstractThe marine medaka Oryzias melastigma has often been used as a marine fish model to investigate the biological responses to environmental stresses and pollutants in marine environments. miRNAs are post transcriptional regulators of many biological processes in a variety of organisms, and have been shown to be affected by environmental stresses, but the novel miRNA profile of marine medaka has not been reported. Using both genome and small RNA sequencings coupled with different bioinformatics analyses, we have discovered 58, 82, 234, and 201 unannotated miRNAs in the brain, liver, ovary and testis tissues of marine medaka, respectively. Furthermore, these novel miRNAs were found to target genes with tissue-specific roles such as neuron development and synaptic transmission in the brain, glucose and fat metabolism in the liver and steroidogenesis in the gonads. We here report, for the first time, novel miRNA profile of marine medaka, which will provide a foundation for future biomarkers and transgenerational studies for the assessment of environmental stresses and pollutions in the marine environments. In a boarder context, our data will provide novel insight into our knowledge of miRNome and miR research. (C) 2016 Elsevier B.V. All rights reserved.
All Author(s) ListLi JW, Lin X, Tse A, Cheung A, Chan TF, Kong RYC, Lai KP, Wu RSS
Journal nameAquatic Toxicology
Year2016
Month6
Day1
Volume Number175
PublisherELSEVIER SCIENCE BV
Pages106 - 116
ISSN0166-445X
eISSN1879-1514
LanguagesEnglish-United Kingdom
KeywordsBiomarkers; Genome sequencing; Marine medaka; Novel microRNA; Small RNA sequencing
Web of Science Subject CategoriesMarine & Freshwater Biology; Toxicology

Last updated on 2020-03-08 at 04:59