Effects of Gegen (Puerariae lobatae Radix) water extract on improving detrusor overactivity in spontaneously hypertensive rats
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AbstractAim: Ex vivo experiments showed that the water extract of Puerariae lobatae Radix (named Gegen in Chinese) induced detrusor relaxation. The aim of this study was to prove the in vivo efficacy of Gegen on improving detrusor overactivity and its possible synergism with darifenacin (a first-line muscarinic receptor-3 inhibitor) in spontaneously hypertensive rats (SHR), a rat model exhibiting symptoms of detrusor overactivity.
All Author(s) ListZhou XL, Lam WP, Tang HC, Koon CM, Cheng L, Lau CBS, Liang W, Leung PC
Journal namePhytomedicine
Year2016
Month6
Day1
Volume Number23
Issue Number6
PublisherELSEVIER GMBH, URBAN & FISCHER VERLAG
Pages672 - 678
ISSN0944-7113
eISSN1618-095X
LanguagesEnglish-United Kingdom
KeywordsDarifenacin; Detrusor overactivity; Gegen; Puerariae lobatae Radix; Spontaneously hypertensive rat; Synergism
Web of Science Subject CategoriesChemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy; Plant Sciences

Last updated on 2020-24-10 at 03:05