Using molecular docking screening for identifying hyperoside as an inhibitor of fatty acid binding protein 4 from a natural product database
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摘要The inhibition of fatty acid binding protein 4 (FABP4) by using small molecules could potentially provide therapeutic opportunities for metabolic disorders treatment. According to the results of our in-house virtual screening on the herbal molecules database, this study reports fiavonols as an ideal scaffold for FABP4 inhibitors development. Among the popillar flavonols examined, we identified hyperoside as a promising FABP4 inhibitor. Identical to the well-known FABP4 inhibitor BMS309403, hyperoside induced lipid accumulation and upregulated peroxisome proliferator-activated receptor gamma (PPAR gamma) protein expression during the adipocyte differentiation process. Furthermore, both PPAR gamma antagonist and FABP4 overexpression attenuated hyperoside-induced adipogenesis, indicating that hyperoside promoted adipogenesis in adipocytes via the FABP4/PPAR gamma pathway. We anticipate hyperoside to be a promising, novel FABP4 inhibitor for antidiabetic drug development. (C) 2015 Elsevier Ltd. All rights reserved.
著者Wang Y, Lin HQ, Xiao CY, Law WK, Hu JS, Ip TM, Wan DCC
期刊名稱Journal of Functional Foods
出版年份2016
月份1
日期1
卷號20
出版社ELSEVIER SCIENCE BV
頁次159 - 170
國際標準期刊號1756-4646
語言英式英語
關鍵詞Adipogenesis; Fatty acid binding protein 4 inhibitor; Flavonols; Hyperoside
Web of Science 學科類別Food Science & Technology

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