The effects of formulation and serum albumin on the in vitro photodynamic activity of zinc(II) phthalocyanines substituted with sulfonated quinolineoxy groups
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摘要Three zinc(II) phthalocyanines substituted with sulfonated quinolineoxy groups, including the mono-alpha-substituted 1, tetra-alpha-substituted 3, and tetra-beta-substituted 4 were synthesized and characterized. These compounds (in deprotonated form) were water-soluble and could be formulated with Cremophor EL or phosphate buffered saline. When formulated with phosphate buffered saline, the serum albumin exerted an important effect on the aggregation tendency and spectroscopic properties of these compounds in biological media. In the case of phosphate buffered saline formulation, the photocytotoxicity followed the order 3 > 4 >> 1 for both human colon carcinoma HT29 and human hepatocarcinoma HepG2 cell lines as a result of their different aggregation tendency. Interestingly, when formulated with Cremophor EL, 1 showed the highest photocytotoxicity not only due to its highest cellular uptake but also due to the reduced aggregation. In both of these formulated systems, the tetra-alpha-substituted compound 3 exhibited a higher potency than the tetra-beta-substituted analogue 4. (C) 2016 Elsevier Ltd. All rights reserved.
著者Lan WL, Liu FR, Ke MR, Lo PC, Fong WP, Ng DKP, Huang JD
期刊名稱Dyes and Pigments
出版年份2016
月份5
日期1
卷號128
出版社ELSEVIER SCI LTD
頁次215 - 225
國際標準期刊號0143-7208
電子國際標準期刊號1873-3743
語言英式英語
關鍵詞Albumin; Formulation; Photodynamic therapy; Structure-activity relationship; Synthesis; Zinc(II) phthalocyanine
Web of Science 學科類別Chemistry; Chemistry, Applied; Engineering; Engineering, Chemical; Materials Science; Materials Science, Textiles

上次更新時間 2020-24-10 於 02:58