Association of gene expression and methylation of UQCRC1 to the predisposition of Alzheimer's disease in a Chinese population
Publication in refereed journal


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摘要DNA methylation is an important epigenetic mechanism for gene regulation and it is well established there is association between aging and DNA methylation. Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by amyloid plaque deposition and formation of neurofibrillary tangles. In this study, we examined the correlation between DNA methylation and gene expression of seven genes including CTSB, CTSD, DDT, TSC1, NRD1, UQCRC1 and NDUFA6 and its effect on the risk of AD in a Chinese population. Our finding showed significantly increased gene expression of these 7 genes in AD patients (2.7-fold-8.6-fold). UQCRC1 was highly methylated in AD patients and there was strong positive correlation between gene expression level and methylation status of UQCRC1 (p < 0.001). Further analysis showed the methylation status of UQCRC1 was significantly associated with gene expression of NRD1, DDT, CTSB and CTSD, suggested the regulatory mechanism on these 4 genes by UQCRC1. Our study further suggested the role of methylation in gene regulation and the role in AD. (C) 2016 Elsevier Ltd. All rights reserved.
著者Ma SL, Tang NLS, Lam LCW
期刊名稱Journal of Psychiatric Research
出版年份2016
月份5
日期1
卷號76
出版社PERGAMON-ELSEVIER SCIENCE LTD
頁次143 - 147
國際標準期刊號0022-3956
電子國際標準期刊號1879-1379
語言英式英語
關鍵詞Alzheimer's disease; Gene expression; Genetics; Methylation
Web of Science 學科類別Psychiatry

上次更新時間 2020-12-08 於 00:33