Turmeric ethanolic extract possesses stronger inhibitory activities on colon tumour growth than curcumin - The importance of turmerones
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摘要The active ingredient curcuminoid (including curcumin, demethoxycurcumin and bisdemethoxycurcumin) from the Asian medicinal and culinary herb turmeric possesses anti-tumour effects, but poor oral absorption in the intestine impedes its widespread clinical application. Our previous study showed that turmerones increased the accumulation of curcumin inside colonic cells. The present study demonstrates the enhanced anti proliferative and anti-angiogenic activities of curcumin in the presence of turmerones in human colon cancer cells and endothelial cells, respectively. Furthermore, in HT29 tumour xenograft-bearing mice fed with curcumin alone or turmeric ethanolic extract (in which the concentration of curcumin was kept the same), the tumour burden of turmeric extract-fed mice was the lowest, suggesting turmeric extract provided better anti-tumour activities than the same amount of curcumin alone did. The superior anti-tumour effects of turmeric extract, which contains curcumin, turmerones and other constituents, were verified in tumour bearing mice, indicating the potential use of turmeric for colorectal cancer adjuvant therapy. (C) 2016 Elsevier Ltd. All rights reserved.
著者Yue GGL, Jiang L, Kwok HF, Lee JKM, Chan KM, Fung KP, Leung PC, Lau CBS
期刊名稱Journal of Functional Foods
出版年份2016
月份4
日期1
卷號22
出版社ELSEVIER SCIENCE BV
頁次565 - 577
國際標準期刊號1756-4646
語言英式英語
關鍵詞Angiogenesis; Colorectal cancer; Curcuma longa; Curcumin; Synergism; Turmerone
Web of Science 學科類別Food Science & Technology

上次更新時間 2020-05-12 於 00:40