Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells
Publication in refereed journal

香港中文大學研究人員

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摘要Antrodia camphorata is a Taiwanese-specific fungus which has been used clinically to treat hypertension, immune- and liver-related diseases and cancer; however, it has never been studied in type 2 diabetes mellitus (T2DM). Hyperglycemia in T2DM causes endoplasmic reticulum (ER) stress, leading to beta-cell dysfunction. During chronic ER stress, misfolded proteins accumulate and initiate beta-cell apoptosis. Moreover, 13-cell dysfunction leads to defect in insulin secretion, which is the key process in the development and progression of T2DM. Therefore, the aim of the present study was to examine the effects of A. carnphorata on insulin secretion and ER stress induced apoptosis in a mouse f)-cell line, MIN6, and their underlying mechanisms. We demonstrated that the ethanolic extract of A. camphorata increased glucose induced insulin secretion dose-dependently through peroxisome proliferator-activated receptor-gamma (PPAR-y) pathway, and upregulated genes that were involved in insulin secretion, including PPAR-gamma, glucose transporter-2 and glucokinase. Furthermore, A. camphorata slightly increased cell proliferation, as well as protected from ER stress induced apoptosis in MIN6 cells. In conclusion, this study provided evidences that A. camphorata might have anti-diabetic effects and could be a novel drug for T2DM.
著者Vong CT, Tseng HHL, Kwan YW, Lee SMY, Hoi MPM
期刊名稱Frontiers in Pharmacology
出版年份2016
月份3
日期21
卷號7
出版社FRONTIERS MEDIA SA
國際標準期刊號1663-9812
語言英式英語
關鍵詞Antrodia camphorata; insulin secretion; pancreatic beta-cell death; PPAR-gamma; type 2 diabetes mellitus
Web of Science 學科類別Pharmacology & Pharmacy

上次更新時間 2020-14-09 於 02:28