Research protocol: effect of natural S-equol on blood pressure and vascular function- a six-month randomized controlled trial among equol non-producers of postmenopausal women with prehypertension or untreated stage 1 hypertension
Publication in refereed journal

Times Cited
Altmetrics Information

Other information
AbstractBackground: Although higher habitual soy intake is associated with lower blood pressure (BP) and stroke incidence, clinical trials using soy protein or isoflavones on cardiovascular risks yielded inconsistent results. The discrepancies are hypothesized to be due to the individuals' intestinal bacterial capacity to metabolite isoflavones daidzein into equol. Animal and in vitro studies have revealed that equol has stronger estrogen-like and anti-oxidative activity than isoflavones and possesses natriuretic and vasorelaxant properties which may play an important role in the prevention of hypertension. However, no clinical trial has examined the effect of equol on BP. We thus propose a 24-week randomized controlled trial to test the effectiveness of natural S-equol on BP and vascular function among equol non-producers.
All Author(s) ListLiu ZM, Ho SC, Chen YM, Xie YJ, Huang ZG, Ling WH
Journal nameBMC Complementary and Alternative Medicine
Volume Number16
LanguagesEnglish-United Kingdom
KeywordsBlood pressure, Equol, Postmenopausal women, Supplementation, Vascular function
Web of Science Subject CategoriesIntegrative & Complementary Medicine

Last updated on 2021-20-06 at 00:06