PDZ-Reactive Peptide Activates Ephrin-B Reverse Signaling and Inhibits Neuronal Chemotaxis
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AbstractIntracellular reactions on nonenzymatic proteins that activate cellular signals are rarely found. We report one example here that a designed peptide derivative undergoes a nucleophilic reaction specifically with a cytosolic PDZ protein inside cells. This reaction led to the activation of ephrin-B reverse signaling, which subsequently inhibited SDF-1 induced neuronal chemotaxis of human neuroblastoma cells and mouse cerebellar granule neurons. Our work provides direct evidence that PDZ-RGS3 bridges ephrin-B reverse signaling and SDF-1 induced G protein signaling for the first time.
All Author(s) ListYu YS, Liu M, Ng TT, Huang F, Nie YY, Wang R, Yao ZP, Li ZG, Xia J
Journal nameACS Chemical Biology
Detailed description2016.
Year2016
Month1
Day1
Volume Number11
Issue Number1
PublisherAMER CHEMICAL SOC
Pages149 - 158
ISSN1554-8929
eISSN1554-8937
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesBiochemistry & Molecular Biology

Last updated on 2020-13-10 at 02:19