Blood Pyrrole-Protein Adducts-A Biomarker of Pyrrolizidine Alkaloid-Induced Liver Injury in Humans
Publication in refereed journal


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摘要Pyrrolizidine alkaloids (PAs) induce liver injury (PA-ILI) and is very likely to contribute significantly to drug-induced liver injury (DILI). In this study we used a newly developed ultra-high performance liquid chromatography-triple quadrupole-mass spectrometry (UHPLC-MS)-based method to detect and quantitate blood pyrrole-protein adducts in DILI patients. Among the 46 suspected DILI patients, 15 were identified as PA-ILI by the identification of PA-containing herbs exposed. Blood pyrrole-protein adducts were detected in all PA-ILI patients (100%). These results confirm that PA-ILI is one of the major causes of DILI and that blood pyrrole-protein adducts quantitated by the newly developed UHPLC-MS method can serve as a specific biomarker of PA-ILI.
著者Ruan JQ, Gao H, Li N, Xue JY, Chen J, Ke CQ, Ye Y, Fu PPC, Zheng J, Wang JY, Lin G
期刊名稱Journal of Environmental Science and Health, Part C
詳細描述To ORKTS: doi: 10.1080/10590501.2015.1096882
出版年份2015
月份10
日期2
卷號33
期次4
出版社TAYLOR & FRANCIS INC
頁次404 - 421
國際標準期刊號1059-0501
電子國際標準期刊號1532-4095
語言英式英語
關鍵詞hepatic sinusoidal obstruction syndrome; hepatotoxicity; pyrrole-protein adducts; pyrrolizidine alkaloids
Web of Science 學科類別Environmental Sciences; Environmental Sciences & Ecology; Oncology; Toxicology

上次更新時間 2020-10-10 於 23:52