Blood Pyrrole-Protein Adducts-A Biomarker of Pyrrolizidine Alkaloid-Induced Liver Injury in Humans
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AbstractPyrrolizidine alkaloids (PAs) induce liver injury (PA-ILI) and is very likely to contribute significantly to drug-induced liver injury (DILI). In this study we used a newly developed ultra-high performance liquid chromatography-triple quadrupole-mass spectrometry (UHPLC-MS)-based method to detect and quantitate blood pyrrole-protein adducts in DILI patients. Among the 46 suspected DILI patients, 15 were identified as PA-ILI by the identification of PA-containing herbs exposed. Blood pyrrole-protein adducts were detected in all PA-ILI patients (100%). These results confirm that PA-ILI is one of the major causes of DILI and that blood pyrrole-protein adducts quantitated by the newly developed UHPLC-MS method can serve as a specific biomarker of PA-ILI.
All Author(s) ListRuan JQ, Gao H, Li N, Xue JY, Chen J, Ke CQ, Ye Y, Fu PPC, Zheng J, Wang JY, Lin G
Journal nameJournal of Environmental Science and Health, Part C
Detailed descriptionTo ORKTS: doi: 10.1080/10590501.2015.1096882
Year2015
Month10
Day2
Volume Number33
Issue Number4
PublisherTAYLOR & FRANCIS INC
Pages404 - 421
ISSN1059-0501
eISSN1532-4095
LanguagesEnglish-United Kingdom
Keywordshepatic sinusoidal obstruction syndrome; hepatotoxicity; pyrrole-protein adducts; pyrrolizidine alkaloids
Web of Science Subject CategoriesEnvironmental Sciences; Environmental Sciences & Ecology; Oncology; Toxicology

Last updated on 2020-20-09 at 01:49