Biological activities of ribosome-inactivating proteins and their possible applications as antimicrobial, anticancer, and anti-pest agents and in neuroscience research
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摘要Ribosome-inactivating proteins (RIPs) are enzymes which depurinate ribosomal RNA (rRNA), thus impeding the process of translation resulting in inhibition of protein synthesis. They are produced by various organisms including plants, fungi and bacteria. RIPs from plants are linked to plant defense due to their antiviral, antifungal, antibacterial, and insecticidal activities in which they can be applied in agriculture to combat microbial pathogens and pests. Their anticancer, antiviral, embryotoxic, and abortifacient properties may find medicinal applications. Besides, conjugation of RIPs with antibodies or other carriers to form immunotoxins has been found useful to research in neuroscience and anticancer therapy.
著者Akkouh O, Ng TB, Cheung RCF, Wong JH, Pan WL, Ng CCW, Sha O, Shaw PC, Chan WY
期刊名稱Applied Microbiology and Biotechnology
出版年份2015
月份12
日期1
卷號99
期次23
出版社SPRINGER
頁次9847 - 9863
國際標準期刊號0175-7598
電子國際標準期刊號1432-0614
語言英式英語
關鍵詞Anticancer; Antifungal; Antiviral; Insecticidal; Ribosome-inactivating proteins
Web of Science 學科類別Biotechnology & Applied Microbiology

上次更新時間 2020-20-09 於 01:47