Biological activities of ribosome-inactivating proteins and their possible applications as antimicrobial, anticancer, and anti-pest agents and in neuroscience research
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AbstractRibosome-inactivating proteins (RIPs) are enzymes which depurinate ribosomal RNA (rRNA), thus impeding the process of translation resulting in inhibition of protein synthesis. They are produced by various organisms including plants, fungi and bacteria. RIPs from plants are linked to plant defense due to their antiviral, antifungal, antibacterial, and insecticidal activities in which they can be applied in agriculture to combat microbial pathogens and pests. Their anticancer, antiviral, embryotoxic, and abortifacient properties may find medicinal applications. Besides, conjugation of RIPs with antibodies or other carriers to form immunotoxins has been found useful to research in neuroscience and anticancer therapy.
All Author(s) ListAkkouh O, Ng TB, Cheung RCF, Wong JH, Pan WL, Ng CCW, Sha O, Shaw PC, Chan WY
Journal nameApplied Microbiology and Biotechnology
Year2015
Month12
Day1
Volume Number99
Issue Number23
PublisherSPRINGER
Pages9847 - 9863
ISSN0175-7598
eISSN1432-0614
LanguagesEnglish-United Kingdom
KeywordsAnticancer; Antifungal; Antiviral; Insecticidal; Ribosome-inactivating proteins
Web of Science Subject CategoriesBiotechnology & Applied Microbiology

Last updated on 2020-31-07 at 02:20