Magnetite Nanostructured Porous Hollow Helical Microswimmers for Targeted Delivery
Publication in refereed journal


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摘要Bacteria-inspired magnetic helical micro-/nanoswimmers can be actuated and steered in a fuel-free manner using a low-strength rotating magnetic field, generating remotely controlled 3D locomotion with high precision in a variety of biofluidic environments. They are therefore envisioned for biomedical applications related to targeted diagnosis and therapy. In this article, a porous hollow microswimmer possessing an outer shell aggregated by mesoporous spindle-like magnetite nanoparticles (NPs) and a helical-shaped inner cavity is proposed. The fabrication is straightforward via a cost-effective mass-production process of biotemplated synthesis using helical microorganisms. Here, Spirulina-based fabrication is demonstrated as an example. The fabricated microswimmers are superparamagnetic and exhibit low cytotoxicity. They are also capable of performing structural disassembly to form individual NPs using ultrasound when needed. For the first time in the literature of helical microswimmers, a porous hollow architecture is successfully constructed, achieving an ultrahigh specific surface area for surface functionalization and enabling diffusion-based cargo loading/release. Furthermore, experimental and analytical results indicate better swimming performance of the microswimmers than the existing non-hollow helical micromachines of comparable sizes and dimensions. These characteristics of the as-proposed microswimmers suggest a novel microrobotic tool with high loading capacity for targeted delivery of therapeutic/imaging agents in vitro and in vivo.
著者Yan XH, Zhou Q, Yu JF, Xu TT, Deng Y, Tang T, Feng Q, Bian LM, Zhang Y, Ferreira A, Zhang L
期刊名稱Advanced Functional Materials
出版年份2015
月份9
日期2
卷號25
期次33
出版社WILEY-V C H VERLAG GMBH
頁次5333 - 5342
國際標準期刊號1616-301X
電子國際標準期刊號1616-3028
語言英式英語
關鍵詞biotemplated synthesis; hollow helical microswimmers; magnetic actuation; mesoporous nanoparticles; targeted delivery
Web of Science 學科類別Chemistry; Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science; Materials Science, Multidisciplinary; Nanoscience & Nanotechnology; Physics; Physics, Applied; Physics, Condensed Matter; Science & Technology - Other Topics

上次更新時間 2021-03-04 於 01:09