Incidence and Causes of Aconitum Alkaloid Poisoning in Hong Kong from 1989 to 2010
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AbstractAconite roots contain Aconitum alkaloids, which are highly toxic cardiotoxins and neurotoxins. In this review, the main objective was to determine the incidence and causes of Aconitum alkaloid poisoning in Hong Kong between 1989 and 2010, based on six published reports from the territory-wide poison control units. In the New Territories East of Hong Kong, the incidence of aconite poisoning showed a sudden and sustained decrease from 0.60 (1989-1991) to 0.16 (1992-1993) and 0.17 (1996-1998) per 100000 population, after publicity measures in late 1991 to promote awareness of the toxicity of aconite roots. In the whole of Hong Kong, the incidence of aconite poisoning was even lower in January 2000-June 2004 (0.03 per 100000 population). However, aconite poisoning became more common again in April 2004-July 2009 and 2008-2010 (0.15 and 0.28 per 100000 population). Overdoses and use of inadequately processed aconite roots were important causes. As from 2004 to 2009, hidden' aconite poisoning (toxicity caused by contaminants in other dispensed herbs) emerged as an important cause. It is important to continue the safety monitoring of potent herbs and the networking of poison control units. Further systematic studies would be required to identify the likely sources of contamination of herbs. Copyright (c) 2015 John Wiley & Sons, Ltd.
All Author(s) ListChan TYK
Journal namePhytotherapy Research
Year2015
Month8
Day1
Volume Number29
Issue Number8
PublisherWILEY-BLACKWELL
Pages1107 - 1111
ISSN0951-418X
eISSN1099-1573
LanguagesEnglish-United Kingdom
Keywordsaconite poisoning; aconite roots; Aconitum alkaloids; Hong Kong; traditional medicine
Web of Science Subject CategoriesChemistry, Medicinal; Pharmacology & Pharmacy

Last updated on 2020-03-07 at 01:13