Alterations of tendons in diabetes mellitus: what are the current findings?
Publication in refereed journal


Times Cited
Web of Science8WOS source URL (as at 29/05/2020) Click here for the latest count
Altmetrics Information
.

Other information
AbstractAs a connective tissue, tendon connects the muscle and bone, and plays the key role in the locomotor system. Some previous studies have shown the pathological alternations in diabetic tendons, which might result in the structural and functional changes, and even accelerate the process of diabetic foot. In this review, we examined the current findings of the diabetic tendons in the form of various aspects, and summarized the clinical presentation, imaging, biomechanical, histopathological, cellular and molecular abnormalities in the diabetic tendons. The progress of diabetic tendon damage is complicated and the main hypotheses include the excessive accumulation of AGEs, the altered inflammatory response, neovascularization and insensitive neuropathy. However, the cellular and molecular mechanisms of these alterations are still ambiguous. Tendon stem/progenitor cells (TSPCs) have been discovered to play important roles in both tendon physiology and tendon pathology. Recently, we identified TSPCs from patellar tendons in our well-established diabetic rat model and found impaired tenogenic differentiation potential of these cells. We proposed a new hypothesis that the impaired cell functions of diabetic TSPCs might be the underlying cellular and molecular mechanism of the diabetic tendon alternations. These findings should be helpful to establish a better therapeutic strategy for diabetic tendon repair and regeneration.
All Author(s) ListShi L, Rui YF, Li G, Wang C
Journal nameInternational Orthopaedics
Detailed description2015
Year2015
Month8
Day1
Volume Number39
Issue Number8
PublisherSPRINGER
Pages1465 - 1473
ISSN0341-2695
eISSN1432-5195
LanguagesEnglish-United Kingdom
KeywordsDiabetes mellitus; Tendon repair and regeneration; Tendon stem/progenitor cells
Web of Science Subject CategoriesOrthopedics

Last updated on 2020-30-05 at 02:36