Herb-drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, anti-inflammatory effect and gastric damage in rats
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AbstractEthnopharmacological relevance: Scutellariae Radix (SR), the dried root of Scutellariae baicalensis Georgi, has a lot in common with non-steroidal anti-inflammatory drugs (NSAIDs). Their similarities in therapeutic action (anti-inflammation) and metabolic pathways (phase II metabolisms) may lead to co-administration by patients with the potential of pharmacokinetic and/or pharmacodynamic interactions. The current study aims to investigate the potential interactions between SR and an NSAID, mefenamic acid (MEF), on the overall pharmacokinetic dispositions, anti-inflammatory effects and adverse effects in rats.
All Author(s) ListFong SYK, Wong YC, Xie C, Zuo Z
Journal nameJournal of Ethnopharmacology
Volume Number170
Pages106 - 116
LanguagesEnglish-United Kingdom
KeywordsHerb-drug interaction; NSAIDs; Pharmacodynamics; Pharmacokinetics; Scutellariae Radix; Traditional Chinese medicine
Web of Science Subject CategoriesChemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy; Plant Sciences

Last updated on 2020-24-10 at 02:40