Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons
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摘要Despite advances in promoting axonal regeneration after adult central nervous system injury, elicitation of a large number of lesion-passing axons reform active synaptic connections with natural target neurons remains limited. By deleting both Pten and Socs3 in retinal ganglion cells, we report that optic nerve axons after prechiasm lesion robustly reinnervate the hypothalamus, form new synapses with neurons in the suprachiasmatic nucleus (SCN), and re-integrate with the existing circuitry. Photic or electric stimulation of the retinal axons induces neuronal response in SCN. However both the innervation pattern and evoked responses are not completely restored by the regenerating axons, suggesting that combining with other strategies is necessary to overcome the defective rewiring. Our results support that boosting the intrinsic growth capacity in injured neurons promotes axonal reinnervation and rewiring. (C) 2015 Published by Elsevier Inc.
著者Li SS, He QH, Wang H, Tang XM, Ho KW, Gao X, Zhang Q, Shen Y, Cheung A, Wong F, Wong YH, Ip NY, Jiang LW, Yung WH, Liu K
期刊名稱Neurobiology of Disease
出版年份2015
月份1
日期1
卷號73
出版社ACADEMIC PRESS INC ELSEVIER SCIENCE
頁次366 - 376
國際標準期刊號0969-9961
電子國際標準期刊號1095-953X
語言英式英語
關鍵詞Axon regeneration and rewiring; Intrinsic mechanisms; Pre-chiasm lesion; Retinal ganglion cells; Suprachiasmatic nucleus
Web of Science 學科類別Neurosciences; Neurosciences & Neurology

上次更新時間 2020-10-10 於 23:45