Antioxidant and Antiangiogenic Properties of Phenolic Extract from Pleurotus tuber-regium
Publication in refereed journal

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其它資訊
摘要Pleurotus tuber-regium (Fries) Singer (PTR), both an edible and a medicinal mushroom also known as tiger milk mushroom, has experienced growing popularity and economic importance due to its flavor, nutritive value, and medicinal effects. In this study, the antioxidant and antiangiogenic activities of a 60% ethanol extract (EE) obtained from the sclerotium of PTR were investigated. Typical phenolic compounds including protocatechuic, chlorogenic, syringic, ferulic, and folic acid were identified and quantified in EE by the HPLC-UV-ESI/MS analyses. EE possessed strong antioxidant activity and could dose-dependently inhibit vascular endothelial growth factor (VEGF)-induced human umbilical vein endothelial cells (HUVEC) migration and tube formation. qPCR results showed that VEGF-induced FGF, ANG-Tie, and MMP gene expression as well as VEGFR were down-regulated at the mRNA level after treated with EE, suggesting that multiple molecular targets related to angiogenesis was involved. Furthermore, EE also inhibited the formation of subintestinal vessel plexus (SIVs) in zebrafish embryos in vivo. All of these suggested that EE of PTR could be the source of potential inhibitors to target angiogenesis.
著者Lin SL, Lai TC, Chen L, Kwok HF, Lau CBS, Cheung PCK
期刊名稱Journal of Agricultural and Food Chemistry
出版年份2014
月份10
日期1
卷號62
期次39
出版社AMER CHEMICAL SOC
頁次9488 - 9498
國際標準期刊號0021-8561
電子國際標準期刊號1520-5118
語言英式英語
關鍵詞antiangiogenesis, antioxidant, phenolic extract, Pleurotus tuber-regium
Web of Science 學科類別Agriculture; Agriculture, Multidisciplinary; Chemistry; Chemistry, Applied; Food Science & Technology

上次更新時間 2020-05-12 於 00:20