Kinetic Entrapment of a Hidden Curcumin Cocrystal with Phloroglucinol
Publication in refereed journal

香港中文大學研究人員

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替代計量分析
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摘要The existence of a cocrystal between curcumin (CUR) and phloroglucinol (PHL) was suspected but could not be demonstrated in a recent systematic effort to synthesize novel curcumin cocrystals. We hypothesize that the elusive CURPHL cocrystal is a kinetically stable form that can be prepared by trapping it using a fast solvent removal crystallization process. The polarity of crystallization solvent and relative solubility of cocrystal formers in the solvent appear to be critical parameters governing the phase purity of the resulting cocrystal. Organic solvents of higher polarity and in which the cocrystal formers exhibited congruent solubility tended to afford a purer cocrystal phase. Essentially phase-pure CURPHL cocrystals were successfully obtained from acetone, and their 1:1 stoichiometry was confirmed by differential scanning calorimetry and solid state nuclear magnetic resonance spectroscopy. Compared with the individual component phases, the cocrystal displayed reduced hygroscopicity and improved tabletability. However, the intrinsic dissolution rate of the cocrystal showed no significant improvement compared with the pure CUR crystal due to the instantaneous conversion of the cocrystal to CUR at its surface upon contact with the dissolution medium.
著者Chow SF, Shi LM, Ng WW, Leung KHY, Nagapudi K, Sun CC, Chow AHL
期刊名稱Crystal Growth and Design
出版年份2014
月份10
日期1
卷號14
期次10
出版社AMER CHEMICAL SOC
頁次5079 - 5089
國際標準期刊號1528-7483
電子國際標準期刊號1528-7505
語言英式英語
Web of Science 學科類別Chemistry; Chemistry, Multidisciplinary; Crystallography; Materials Science; Materials Science, Multidisciplinary

上次更新時間 2020-21-09 於 01:11