Chronic alcohol consumption from adolescence to adulthood in mice - Hypothalamic gene expression changes in insulin-signaling pathway
Publication in refereed journal

香港中文大學研究人員

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摘要Adolescence is a developmental stage vulnerable to alcohol drinking-related problems, and alcohol exposure during adolescence may lead to long-lasting consequences. The hypothalamus is a key brain region for food and water intake regulation as well as weight control, and is one of the alcohol-sensitive brain. regions. However, it is not known what the alcohol effect is on the hypothalamus following adolescent alcohol intake, chronically over adolescent development, at moderate levels. We employed a model of chronic moderate alcohol intake from adolescence to adulthood in mice, and analyzed the effect of alcohol. on growth and weight gain, as well as hypothalamic gene expression patterns. The results indicated that chronic alcohol consumption during adolescence, even at moderate levels, led to both a reduction in weight gain in mice, and considerable gene expression changes in the hypothalamus. Pathway analysis and real-time PCR identified the type II diabetes mellitus and the insulin-signaling pathways as being the hypothalamic pathways affected by chronic alcohol. Our findings from the mouse alcohol consumption study therefore serve as a potential warning against alcohol consumption during adolescence, such as in teens and college students. (C) 2014 Elsevier Inc. All rights reserved.
著者Wang K, Song HG, Jin ML, Xiao HS, Zhao GP, Zou H, Yu L
期刊名稱Alcohol
出版年份2014
月份9
日期1
卷號48
期次6
出版社ELSEVIER SCIENCE INC
頁次571 - 578
國際標準期刊號0741-8329
電子國際標準期刊號1873-6823
語言英式英語
關鍵詞Adolescence; Chronic alcohol drinking; Gene expression; Hypothalamus; Insulin-signaling pathway; Type II diabetes mellitus
Web of Science 學科類別Pharmacology & Pharmacy; Substance Abuse; Toxicology

上次更新時間 2020-25-11 於 02:03