Chronic alcohol consumption from adolescence to adulthood in mice - Hypothalamic gene expression changes in insulin-signaling pathway
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AbstractAdolescence is a developmental stage vulnerable to alcohol drinking-related problems, and alcohol exposure during adolescence may lead to long-lasting consequences. The hypothalamus is a key brain region for food and water intake regulation as well as weight control, and is one of the alcohol-sensitive brain. regions. However, it is not known what the alcohol effect is on the hypothalamus following adolescent alcohol intake, chronically over adolescent development, at moderate levels. We employed a model of chronic moderate alcohol intake from adolescence to adulthood in mice, and analyzed the effect of alcohol. on growth and weight gain, as well as hypothalamic gene expression patterns. The results indicated that chronic alcohol consumption during adolescence, even at moderate levels, led to both a reduction in weight gain in mice, and considerable gene expression changes in the hypothalamus. Pathway analysis and real-time PCR identified the type II diabetes mellitus and the insulin-signaling pathways as being the hypothalamic pathways affected by chronic alcohol. Our findings from the mouse alcohol consumption study therefore serve as a potential warning against alcohol consumption during adolescence, such as in teens and college students. (C) 2014 Elsevier Inc. All rights reserved.
All Author(s) ListWang K, Song HG, Jin ML, Xiao HS, Zhao GP, Zou H, Yu L
Journal nameAlcohol
Year2014
Month9
Day1
Volume Number48
Issue Number6
PublisherELSEVIER SCIENCE INC
Pages571 - 578
ISSN0741-8329
eISSN1873-6823
LanguagesEnglish-United Kingdom
KeywordsAdolescence; Chronic alcohol drinking; Gene expression; Hypothalamus; Insulin-signaling pathway; Type II diabetes mellitus
Web of Science Subject CategoriesPharmacology & Pharmacy; Substance Abuse; Toxicology

Last updated on 2021-02-03 at 00:48