Capsaicinoids but Not Their Analogue Capsinoids Lower Plasma Cholesterol and Possess Beneficial Vascular Activity
Publication in refereed journal

Times Cited
Web of Science17WOS source URL (as at 22/09/2021) Click here for the latest count
Altmetrics Information

Other information
AbstractCapsaicinoids exist in chili peppers, whereas capsinoids are present in some sweet peppers. The present study investigated the effects of capsaicinoids and capsinoids on plasma lipids, relaxation of the aorta, atherosclerotic plaque development, and fecal sterol excretion in hamsters fed a high-cholesterol diet. Five groups of male hamsters were given the control diet or one of the four experimental diets containing 1.3 mmol of capsaicinoids (NL), 2.6 mmol of capsaicinoids (NH), 1.3 mmol of capsinoids (OL), or 2.6 mmol of capsinoids (OH), respectively. Results showed capsaicinoids but not capsinoids could decrease plasma total cholesterol (TC), reduce the formation of atherosclerotic plaque, and relax the aortic artery. This was accompanied by a 28-175% increase in fecal excretion of acidic sterols in hamsters fed the diets containing capsaicinoids. Similarly, capsaicinoids but not capsinoids could decrease the pad weights of epididymal and prerenal adipose tissues. It was concluded that capsaicinoids but not capsinoids could favorably modulate plasma lipids and possess beneficial vascular activity.
All Author(s) ListHuang WH, Cheang WS, Wang XB, Lei L, Liu YW, Ma KY, Zheng FR, Huang Y, Chen ZY
Journal nameJournal of Agricultural and Food Chemistry
Volume Number62
Issue Number33
Pages8415 - 8420
LanguagesEnglish-United Kingdom
Keywordsaorta; atherosclerosis; capsaicinoids; capsinoids; cholesterol; pepper
Web of Science Subject CategoriesAgriculture; Agriculture, Multidisciplinary; AGRICULTURE, MULTIDISCIPLINARY; Chemistry; Chemistry, Applied; CHEMISTRY, APPLIED; Food Science & Technology; FOOD SCIENCE & TECHNOLOGY

Last updated on 2021-23-09 at 00:55