Capsaicinoids but Not Their Analogue Capsinoids Lower Plasma Cholesterol and Possess Beneficial Vascular Activity
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AbstractCapsaicinoids exist in chili peppers, whereas capsinoids are present in some sweet peppers. The present study investigated the effects of capsaicinoids and capsinoids on plasma lipids, relaxation of the aorta, atherosclerotic plaque development, and fecal sterol excretion in hamsters fed a high-cholesterol diet. Five groups of male hamsters were given the control diet or one of the four experimental diets containing 1.3 mmol of capsaicinoids (NL), 2.6 mmol of capsaicinoids (NH), 1.3 mmol of capsinoids (OL), or 2.6 mmol of capsinoids (OH), respectively. Results showed capsaicinoids but not capsinoids could decrease plasma total cholesterol (TC), reduce the formation of atherosclerotic plaque, and relax the aortic artery. This was accompanied by a 28-175% increase in fecal excretion of acidic sterols in hamsters fed the diets containing capsaicinoids. Similarly, capsaicinoids but not capsinoids could decrease the pad weights of epididymal and prerenal adipose tissues. It was concluded that capsaicinoids but not capsinoids could favorably modulate plasma lipids and possess beneficial vascular activity.
All Author(s) ListHuang WH, Cheang WS, Wang XB, Lei L, Liu YW, Ma KY, Zheng FR, Huang Y, Chen ZY
Journal nameJournal of Agricultural and Food Chemistry
Year2014
Month8
Day20
Volume Number62
Issue Number33
PublisherAMER CHEMICAL SOC
Pages8415 - 8420
ISSN0021-8561
eISSN1520-5118
LanguagesEnglish-United Kingdom
Keywordsaorta; atherosclerosis; capsaicinoids; capsinoids; cholesterol; pepper
Web of Science Subject CategoriesAgriculture; Agriculture, Multidisciplinary; AGRICULTURE, MULTIDISCIPLINARY; Chemistry; Chemistry, Applied; CHEMISTRY, APPLIED; Food Science & Technology; FOOD SCIENCE & TECHNOLOGY

Last updated on 2020-06-04 at 01:14