Structure Elucidation and Immunomodulatory Activity of A Beta Glucan from the Fruiting Bodies of Ganoderma Sinense
Publication in refereed journal


引用次數
替代計量分析
.

其它資訊
摘要A polysaccharide named GSP-2 with a molecular size of 32 kDa was isolated from the fruiting bodies of Ganoderma sinense. Its structure was well elucidated, by a combined utilization of chemical and spectroscopic techniques, to be a beta-glucan with a backbone of (1 -> 4)- and (1 -> 6)-Glcp, bearing terminal- and (1 -> 3)-Glcp side-chains at O-3 position of (1 -> 6)-Glcp. Immunological assay exhibited that GSP-2 significantly induced the proliferation of BALB/c mice splenocytes with target on only B cells, and enhanced the production of several cytokines in human peripheral blood mononuclear cells and derived dendritic cells. Besides, the fluorescent labeled GSP-2 was phagocytosed by the RAW 264.7 cells and induced the nitric oxide secretion from the cells.
著者Han XQ, Yue GL, Yue RQ, Dong CX, Chan CL, Ko CH, Cheung WS, Luo KW, Dai H, Wong CK, Leung PC, Han QB
期刊名稱PLoS ONE
詳細描述doi: 10.1371/journal.pone.0100380. eCollection 2014.
出版年份2014
月份7
日期11
卷號9
期次7
出版社PUBLIC LIBRARY SCIENCE
國際標準期刊號1932-6203
語言英式英語
Web of Science 學科類別Multidisciplinary Sciences; MULTIDISCIPLINARY SCIENCES; Science & Technology - Other Topics

上次更新時間 2021-03-03 於 23:06