Asymmetric synthesis of 3,3,5,5-tetrasubstituted 1,2-dioxolanes: total synthesis of epiplakinic acid F
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AbstractThe first enantioselective total synthesis of epiplakinic acid F (1) was achieved through a pivotal step involving a radical-mediated asymmetric peroxidation of vinylcyclopropanes with molecular oxygen to construct highly substituted 1,2-dioxolanes. Subsequent conversions of the chiral 1,2-dioxolanes led to total synthesis of epiplakinic acid F (1) and the confirmation of its absolute configuration. The enantiomer of epiplakinic acid F methyl ester (2) was also prepared.
All Author(s) ListTian XY, Han JW, Zhao Q, Wong HNC
Journal nameOrganic and Biomolecular Chemistry
Volume Number12
Issue Number22
Pages3686 - 3700
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesChemistry; Chemistry, Organic; CHEMISTRY, ORGANIC

Last updated on 2020-02-07 at 03:03