Targeting ribonucleotide reductase M2 subunit by small interfering RNA exerts anti-oncogenic effects in gastric adenocarcinoma
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AbstractRibonucleotide reductase M2 subunit (RRM2) is one of the two subunits of human ribonucleotide reductase which plays a critical role in tumor progression. The aim of the present study was to analyze its expression, clinical significance and biological functions in gastric adenocarcinoma. We observed the upregulation of RRM2 mRNA and protein in all nine gastric cancer cell lines examined. In paired primary gastric cancers, both mRNA and protein levels of RRM2 were significantly upregulated in tumors compared with the corresponding non-tumorous gastric tissues. RRM2 protein expression correlated with higher tumor grade, advanced T stage and poor disease-specific survival. RRM2 knockdown in gastric cancer cell lines AGS, MKN1 and MKN28 significantly suppressed cell proliferation, inhibited monolayer colony formation, reduced cell invasion and induced apoptosis. Downregulation of RRM2 suppressed xenograft formation in vivo. Collectively, these findings suggest that RRM2 plays a crucial role in gastric tumorigenesis and may serve as a potential prognostic marker and therapeutic target in gastric cancer.
All Author(s) ListKang W, Tong JHM, Chan AWH, Zhao JH, Wang SY, Dong YJ, Sin FMC, Yeung S, Cheng ASL, Yu J, To K
Journal nameOncology Reports
Detailed descriptionTo ORKTS: doi: 10.3892/or.2014.3148
Volume Number31
Issue Number6
Pages2579 - 2586
LanguagesEnglish-United Kingdom
Keywordsgastric cancer; ribonucleotide reductase M2 subunit; siRNA
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2021-11-04 at 00:16