SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis
Publication in refereed journal

香港中文大學研究人員

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摘要Aim: Approximately a third of newly diagnosed epilepsy patients do not respond to antiepileptic drugs (AEDs). Evidence suggests that low penetrance variants in the genes of drug targets such as voltage-gated sodium channels may be involved in drug responsiveness. To examine this hypothesis, we compared data from two epilepsy cohorts from Malaysia and Hong Kong, as well as a meta-ana-lysis from published data. Materials & methods: Genotype ana-lysis of 39 polymorphisms located in the SCN1A, SCN2A and SCN3A genes was performed on 1504 epilepsy patients from Malaysia and Hong Kong who were receiving AEDs. Meta-ana-lysis was performed for pooled data of SCN1A rs3812718 and rs2298771, and SCN2A rs17183814 polymorphisms. Results: Our data from the Hong Kong and Malaysia cohorts showed no significant allele, genotype and haplotype association of polymorphisms in the SCN1A, SCN2A, and SCN3A genes with drug responsiveness in epilepsy. This finding was supported by a meta-ana-lysis for SCN1A rs3812718 and rs2298771, and for SCN2A rs17183814 polymorphisms. Conclusion: Our comprehensive study suggests that common polymorphisms in SCN1A, SCN2A and SCN3A do not play major roles in influencing response to AEDs.
著者Haerian BS, Baum L, Kwan P, Tan HJ, Raymond AA, Mohamed Z
期刊名稱Pharmacogenomics
出版年份2013
月份7
日期1
卷號14
期次10
出版社FUTURE MEDICINE LTD
頁次1153 - 1166
國際標準期刊號1462-2416
電子國際標準期刊號1744-8042
語言英式英語
關鍵詞drug responsiveness; epilepsy; polymorphism; SCN1A; SCN2A; SCN3A
Web of Science 學科類別Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

上次更新時間 2020-25-11 於 01:52