Pregnancy Outcomes, Embryonic and Fetal Development in Maternal Exposure to Chinese Medicines
Publication in refereed journal


摘要Chinese medicine is a common name for a collection of Chinese Materia Medica with therapeutic properties for medical treatment and healing. Similar to Western pharmaceuticals, Chinese medicines are not free of risk, and have the potential to cause adverse pregnancy outcomes and affect embryonic and fetal development. However, most clinical data concerning safety of maternal exposure to Chinese medicines during pregnancy are not available and the conclusion remains elusive. Some individual clinical trials of Chinese medicines reported some minor adverse effects during pregnancy, whereas few animal studies identified some adverse maternal and perinatal effects, as well as embryotoxic potentials. Basic research and mechanistic studies of the teratogenicity of Chinese medicines are still lacking. There is an urgent need for testing the safety of Chinese medicines before recommendation and commercialization. Until more reliable and scientific research data become available, clinicians should consider both the risks and benefits before recommending Chinese medicines to pregnant women. More systematic investigations of the safety implications of the use of Chinese medicines are highly recommended, in addition to more clinical trials with a larger sample size to confirm its safety during pregnancy. This review includes a critical overview of available clinical and experimental data and provides directions to study the safety issue of Chinese medicines for pregnancy. Birth Defects Research (Part C) 99:275-291, 2013. (c) 2013 Wiley Periodicals, Inc.
著者Wang CC, Li L, Lau CBS, Leung PC, Fung KP
期刊名稱Birth Defects Research Part C: Embryo Today: Reviews
頁次275 - 291
關鍵詞development; embryotoxicity; herbal medicines; pregnancy
Web of Science 學科類別Developmental Biology; DEVELOPMENTAL BIOLOGY; Reproductive Biology

上次更新時間 2021-14-01 於 00:35