Suppression of PACT-Induced Type I Interferon Production by Herpes Simplex Virus 1 Us11 Protein
Publication in refereed journal

香港中文大學研究人員

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摘要Herpes simplex virus 1 (HSV-1) Us11 protein is a double-stranded RNA-binding protein that suppresses type I interferon production through the inhibition of the cytoplasmic RNA sensor RIG-I. Whether additional cellular mediators are involved in this suppression remains to be determined. In this study, we report on the requirement of cellular double-stranded RNA-binding protein PACT for Us11-mediated perturbation of type I interferon production. Us11 associates with PACT tightly to prevent it from binding with and activating RIG-I. The Us11-deficient HSV-1 was indistinguishable from the Us11-proficient virus in the suppression of interferon production when PACT was compromised. More importantly, HSV-1-induced activation of interferon production was abrogated in PACT knockout murine embryonic fibroblasts. Our findings suggest a new mechanism for viral evasion of innate immunity through which a viral double-stranded RNA-binding protein interacts with PACT to circumvent type I interferon production. This mechanism might also be used by other PACT-binding viral interferon-antagonizing proteins such as Ebola virus VP35 and influenza A virus NS1.
著者Kew C, Lui PY, Chan CP, Liu X, Au SWN, Mohr I, Jin DY, Kok KH
期刊名稱Journal of Virology
出版年份2013
月份12
日期1
卷號87
期次24
出版社AMER SOC MICROBIOLOGY
頁次13141 - 13149
國際標準期刊號0022-538X
電子國際標準期刊號1098-5514
語言英式英語
Web of Science 學科類別Virology; VIROLOGY

上次更新時間 2020-13-10 於 01:59