Preparation and in Vitro Photodynamic Activities of Folate-Conjugated Distyryl Boron Dipyrromethene Based Photosensitizers
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摘要Two folate-conjugated diiododistyryl boron dipyrromethenes have been prepared and characterized with various spectroscopic methods. These conjugates exhibit higher photocytotoxicity toward the KB human nasopharyngeal carcinoma cells, which have high expression of folate receptors When compared with the MCF-7 human breast adenocarcinoma cells, which have low expression of folate receptors. The difference in photocytotoxicity for these two cell lines is particularly large for the conjugate with a shorter oligoethylene glycol linker (compound 11a) as a result of its higher cellular uptake and slightly lower aggregation tendency. Its IC50 value toward KB cells (0.06 mu M) is 43-fold lower than analogue with a longer linker (compound 11b). The length compound 11a shows high affinity toward the endoplasmic lysosomes. that for MCF-7 cells, while the difference is only 6-fold for the of the spacer also affects their subcellular localization. While eticulum of KB cells, conjugate 11b is mainly localized in the lysosomes.
著者Ke MR, Yeung SL, Ng DKP, Fong WP, Lo PC
期刊名稱Journal of Medicinal Chemistry
出版年份2013
月份11
日期14
卷號56
期次21
出版社AMER CHEMICAL SOC
頁次8475 - 8483
國際標準期刊號0022-2623
電子國際標準期刊號1520-4804
語言英式英語
Web of Science 學科類別Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Pharmacology & Pharmacy

上次更新時間 2020-24-10 於 02:21