Advanced technologies for studying circulating tumor cells at the protein level
Publication in refereed journal


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摘要Metastasis is the main cause of cancer death. As the tumor progresses, cells from the primary tumor site are shed into the bloodstream as circulating tumor cells (CTCs). Eventually, these cells colonize other organs and form distant metastases. It is therefore imperative that we gain a better understanding of the biological characteristics of CTCs for development of novel treatment modalities to minimize metastasis-associated cancer deaths. In recent years, rapid developments in technologies for the study of CTCs have taken place. We now have a variety of tools for the isolation and examination of CTCs which were not available before. This review introduces some commonly used protein markers in CTC investigations and summarizes a few advanced technologies which have been successfully applied for studying CTC biology at the protein level.
著者Chan CML, Au TCC, Chan ATC, Ma BBY, Tsui NBY, Ng SSM, Hui EP, Chan LWC, Ho WS, Yung BYM, Wong SCC
期刊名稱Expert Review of Proteomics
出版年份2013
月份12
日期1
卷號10
期次6
出版社EXPERT REVIEWS
頁次579 - 589
國際標準期刊號1478-9450
電子國際標準期刊號1744-8387
語言英式英語
關鍵詞CellSearch; circulating tumor cells; CTC-chip; EPISPOT; immunomagnetic bead; proteomic
Web of Science 學科類別Biochemical Research Methods; BIOCHEMICAL RESEARCH METHODS; Biochemistry & Molecular Biology

上次更新時間 2021-18-01 於 23:50