Advanced technologies for studying circulating tumor cells at the protein level
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AbstractMetastasis is the main cause of cancer death. As the tumor progresses, cells from the primary tumor site are shed into the bloodstream as circulating tumor cells (CTCs). Eventually, these cells colonize other organs and form distant metastases. It is therefore imperative that we gain a better understanding of the biological characteristics of CTCs for development of novel treatment modalities to minimize metastasis-associated cancer deaths. In recent years, rapid developments in technologies for the study of CTCs have taken place. We now have a variety of tools for the isolation and examination of CTCs which were not available before. This review introduces some commonly used protein markers in CTC investigations and summarizes a few advanced technologies which have been successfully applied for studying CTC biology at the protein level.
All Author(s) ListChan CML, Au TCC, Chan ATC, Ma BBY, Tsui NBY, Ng SSM, Hui EP, Chan LWC, Ho WS, Yung BYM, Wong SCC
Journal nameExpert Review of Proteomics
Volume Number10
Issue Number6
Pages579 - 589
LanguagesEnglish-United Kingdom
KeywordsCellSearch; circulating tumor cells; CTC-chip; EPISPOT; immunomagnetic bead; proteomic
Web of Science Subject CategoriesBiochemical Research Methods; BIOCHEMICAL RESEARCH METHODS; Biochemistry & Molecular Biology

Last updated on 2020-25-11 at 01:49