Signaling pathway and molecular subgroups of medulloblastoma
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摘要Medulloblastoma (MB) is the most common malignant brain tumor in children. Although multimodality treatment regimens including surgery, radiotherapy and chemotherapy have greatly improved disease outcome, about one-third of MB patient remains incurable, and many long-term survivors are suffered from deleterious effects due to aggressive treatment. Understanding the signaling pathways and the genetic mechanisms contributed to MB development would be the key to develop novel therapeutic treatment strategies for improving survival and outcome of MB. In this review, we discuss the biological signaling pathways involved in MB pathogenesis. We also go through the current international consensus of four core MB subgroups namely, SHH, WNT, Group 3, and Group 4. This is adopted based on the knowledge of genomic complexity of MB as analyzed by recent high-throughput genomic technology. We talk about immunohistochemistry assays established to determine molecular subgroup affiliation. In the last part of review, we discuss how identification of molecular subgroups is going to change our routine disease diagnosis and clinical management.
著者Li KKW, Lau KM, Ng HK
期刊名稱International Journal of Clinical and Experimental Pathology
出版年份2013
月份1
日期1
卷號6
期次7
出版社E-CENTURY PUBLISHING CORP
頁次1211 - 1222
國際標準期刊號1936-2625
語言英式英語
關鍵詞Medulloblastoma; molecular subgroups; signaling pathway
Web of Science 學科類別Oncology; ONCOLOGY; Pathology; PATHOLOGY

上次更新時間 2021-25-01 於 01:12