Angiogenic Effects of Danshen and Gegen Decoction on Human Endothelial Cells and Zebrafish Embryos
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AbstractCoronary artery diseases (CAD) are the most common diseases worldwide. Despite improvements in standard heart surgeries, many patients still progress to advanced stages. Recent clinical trials have shown encouraging results that pro-angiogenic treatment improved heart function recovery. Danshen and Gegen have been widely used in treating heart diseases for thousands of years in China. Our previous findings showed that a Danshen and Gegen decoction in weight ratio of 7 to 3 (DG) had a potential vasodilation effect and provided cardiac protection in patients with atherosclerosis. In the present study, we examine the therapeutic potential of Danshen and Gegen decoction (DG) in CAD. A screening using a transgenic zebrafish embryo model was performed to check vessel sprouting. In addition, human microvascular endothelial cells (HMEC-1) were used to explore underlying mechanisms. Our results revealed that DG enhanced the sprouting of sub-intestinal vessels (SIVs) of zebrafish embryos. Sprout intensity in the high concentration DG-treated group (500 mu g/ml) was significantly higher than the control group. In vitro experiments showed that DG also induced HMEC-1 cell proliferation, migration, and tube formation. In conclusion, DG possesses pro-angiogenic properties by inducing endothelial cell activation, which may have therapeutic potential for the treatment of CAD.
All Author(s) ListHu F, Chan JYW, Koon CM, Fung KP
Journal nameAmerican Journal of Chinese Medicine
Volume Number41
Issue Number4
Pages887 - 900
LanguagesEnglish-United Kingdom
KeywordsCoronary Artery Diseases; DG Decoction; Migration; Tube Formation
Web of Science Subject CategoriesGeneral & Internal Medicine; Integrative & Complementary Medicine; INTEGRATIVE & COMPLEMENTARY MEDICINE; Medicine, General & Internal; MEDICINE, GENERAL & INTERNAL

Last updated on 2021-11-05 at 00:38