Potential role for human P-glycoprotein in the transport of lacosamide
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摘要Purpose: Antiepileptic drugs (AEDs) do not effectively treat 30-40% of patients with epilepsy. Export of AEDs by P-glycoprotein (Pgp, ABCB1, or MDR1), which is over-expressed in the blood-brain barrier in drug-resistant patients, may be a mechanism for resistance to AEDs. For most recently approved AEDs, whether they are transported by Pgp is unknown. We investigated whether a new AED, lacosamide (LCM), is a substrate of human Pgp.
著者Zhang CB, Chanteux H, Zuo Z, Kwan P, Baum L
期刊名稱Epilepsia
出版年份2013
月份7
日期1
卷號54
期次7
出版社WILEY-BLACKWELL
頁次1154 - 1160
國際標準期刊號0013-9580
電子國際標準期刊號1528-1167
語言英式英語
關鍵詞Lacosamide; P-glycoprotein; Transport
Web of Science 學科類別Clinical Neurology; CLINICAL NEUROLOGY; Neurosciences & Neurology

上次更新時間 2020-25-11 於 01:47