Association of polymorphisms in the Chr18q11.2 locus with tuberculosis in Chinese population
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AbstractA GWAS study has reported that two single nucleotide polymorphisms (SNPs) were associated with predisposition to tuberculosis (TB) in African populations. These two loci represented the long-waited GWAS hits for TB susceptibility. To determine whether these two SNPs are associated with TB in Chinese population, we attempted an replication in a cohort of over one thousand Chinese TB patients and 1,280 healthy controls using melting temperature shift allele-specific genotyping analysis. We found that only SNP rs4331426 was significantly associated with TB in Chinese population (p = 0.011). However, the effect was opposite. The G allele of the SNP in Chinese population is a protective allele (OR = 0.62, 95 % CI 0.44-0.87), while it was the risk allele for African population (OR = 1.19, 95 % CI 1.12-1.26). No significance was found for SNP rs2335704. The results provided an independent support for a role in susceptibility to TB for SNP rs4331426. However, it also indicated that direct predisposition element to TB and the association effects may vary across ethnic groups.
All Author(s) ListWang XY, Tang NLS, Leung CC, Kam KM, Yew WW, Tam CM, Chan CY
Journal nameHuman Genetics
Volume Number132
Issue Number6
Pages691 - 695
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesGenetics & Heredity; GENETICS & HEREDITY

Last updated on 2021-23-09 at 00:42