Prediction of women's long-term cardiometabolic risks using glycemic indices during pregnancy
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摘要Aims: To study the prediction of abnormal glucose tolerance (AGT), diabetes mellitus (DM), hypertension (HT) and metabolic syndrome (MetS) among Chinese women using glycemic indices in the mid-trimester of pregnancy. Methods: A cohort of Chinese women who had had either normal glucose tolerance or gestational diabetes mellitus (GDM) during a pregnancy were assessed at a median of 8 and 15 years post-delivery. All women underwent a 50-g glucose challenge test (GCT) and a 75-g oral glucose tolerance test in the mid-trimester of the index pregnancy. A receiver operating characteristic curve was used to assess the prediction of AGT, DM, HT and MetS. Results: All glycemic indices were significant predictors of AGT and DM, and the 2-h plasma glucose (PG) and GCT were predictive of HT, at both 8 and 15 years post-delivery. MetS can only be predicted by the fasting plasma glucose (FPG) and was confined to 15 years post-delivery. After adjustment for confounding variables, all glycemic indices were still independent predictors of AGT and DM at both 8 and 15 years post-delivery, except for FPG in predicting DM at 8 years, while only the 2-h PG remains an independent predictor of HT at 15 years. The optimal cut-off values for FPG, 2-h PG and GCT are 4.2 mmol/L, 7.2 mmol/L and 7.7 mmol/L, respectively; all are lower than the current cut-off thresholds for the screening and diagnosis of GDM. Conclusions: Women who had a glycemic level below the criteria for a positive screening test and below the diagnostic threshold for GDM still have a significant cardiometabolic risk.
著者Tam WH, Ma RCW, Yang XL, Ko GTC, Lao TTH, Sahota DS, Chan MHM, Lam CWK, Cockram CS, Chan JCN
期刊名稱Journal of Obstetrics and Gynaecology Research
出版年份2013
月份2
日期1
卷號39
期次2
出版社WILEY-BLACKWELL
頁次484 - 491
國際標準期刊號1341-8076
電子國際標準期刊號1447-0756
語言英式英語
關鍵詞diabetes mellitus; gestational diabetes mellitus; hypertension; metabolic syndrome
Web of Science 學科類別Obstetrics & Gynecology; OBSTETRICS & GYNECOLOGY

上次更新時間 2020-20-09 於 03:00