Antibiotic-resistant Propionibacterium acnes among acne patients in a regional skin centre in Hong Kong
Publication in refereed journal


摘要Background There has been no study on antibiotic-resistant Propionibacterium acnes in Hong Kong. Objective We investigated the prevalence and pattern of antibiotic-resistant P. acnes and to identify any associated factors for harbouring the resistant strains. Methods Culture and sensitivity testing of P. acnes to commonly used antibiotics were performed. Resistance to tetracycline was defined at a minimal inhibitory concentration (MIC) of 2 mu g/mL or more; erythromycin at an MIC of 0.5 mu g/mL or more; clindamycin at an MIC of 0.25 mu g/mL or more according to EUCAST. For breakpoints of doxycycline and minocycline, those with an MIC of 1 mu g/mL or more were defined as resistant strains. Results Among the 111 specimens collected from 111 patients, 86 strains of P. acnes were recovered, one from each specimen. Twenty-five specimens had no growth. Forty-seven (54.8%) strains were found to be resistant to one or more antibiotics. Forty-six (53.5%), 18 (20.9%), 14 (16.3%), 14(16.3%) and 14 (16.3%) strains were resistant to clindamycin (CL), erythromycin (EM), tetracycline (TET), doxycycline (DOX) and minocycline (MR) respectively. Ten strains (11.6%) had cross resistance between the MLS antibiotics (erythromycin or clindamycin), one strain (1.2%) had cross resistance among the cyclines and 14 strains (16.4%) had cross resistance between the MLS and cycline antibiotics. Binary logistic regression showed an association between MLS antibiotic resistance with an increased age whereas cycline resistance was associated with the duration of treatment. Conclusions Antibiotic-resistant P. acnes is prevalent in Hong Kong. Dermatologists should be more vigilant in prescribing antibiotics for acne patients.
著者Luk NMT, Hui M, Lee HCS, Fu LH, Liu ZH, Lam LY, Eastel M, Chan YKA, Tang LSN, Cheng TS, Siu FYC, Ng SC, Lai YKD, Ho KM
期刊名稱Journal of the European Academy of Dermatology and Venereology
頁次31 - 36
Web of Science 學科類別Dermatology; DERMATOLOGY

上次更新時間 2021-14-09 於 00:18