Genetically Encodable Design of Ligand "Bundling" on the Surface of Nanoparticles
Publication in refereed journal


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其它資訊
摘要Polyhistidine peptide dendrimer self-assembles on CdSe/ZnS quantum dots (QDs) with very high affinity and stability, a property ascribable to its multivalent geometry. Here we designed a fluorescent protein, GCN-mCherry, that exists as an oligomeric bundled structure in solution as well as on the surface to imitate the structure of a synthetic dendrimer. GCN-mCherry forms a very stable assembly with QDs, which can resist displacement by 500 mM imidazole and the dendrimer peptide, as measured by the Forster resonance energy transfer from QD to mCherry. Our work manifested a prominent stability enhancement of protein-nanoparticle assembly through directional ligand ligand interaction on the surface.
著者Lu Y, Wang JP, Wang JH, Wang L, Au SWN, Xia J
期刊名稱Langmuir
出版年份2012
月份10
日期2
卷號28
期次39
出版社AMER CHEMICAL SOC
頁次13788 - 13792
國際標準期刊號0743-7463
電子國際標準期刊號1520-5827
語言英式英語
Web of Science 學科類別Chemistry; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY; Chemistry, Physical; CHEMISTRY, PHYSICAL; Materials Science; Materials Science, Multidisciplinary; MATERIALS SCIENCE, MULTIDISCIPLINARY

上次更新時間 2020-13-10 於 01:51