Dyspepsia is strongly associated with major depression and generalised anxiety disorder - a community study
Publication in refereed journal


摘要Background The relationship between dyspepsia and psychiatric comorbidity such as anxiety and depression is poorly defined. Previous studies have been limited by lack of standardised diagnostic criteria. Aim To examine the prevalence and comorbidity of dyspepsia as defined by Rome III (6-month duration) with DSM-IV-TR generalised anxiety disorder (GAD) and major depressive episodes (MDE) in the general population. Methods A random population-based telephone survey was done using a questionnaire on symptoms of Rome III Dyspepsia, DSM-IV-TR GAD and MDE and their chronological relationship. Results Of the 2011 respondents 8.0% currently had Rome III Dyspepsia, 3.8% reported GAD and 12.4% reported MDE respectively. Dyspeptic subjects had a twofold increased risk of GAD (OR = 2.03, 95% CI: 1.063.89, P < 0.001) and a threefold increased risk of MDE (OR = 3.56, 95% CI: 2.335.43, P < 0.001). MDE and GAD most often coincided with dyspepsia in onset. Dyspepsia (OR = 2.48, 95% CI: 1.653.72 P < 0.001), MDE (OR = 2.39, 95% CI: 1.643.46, P < 0.001) and female sex (OR = 1.65, 95% CI: 1.212.23, P < 0.001) independently predicted frequent medical consultations. GAD independently predicted high investigation expenditure (OR = 4.65, 95% CI: 1.1518.70, P = 0.03). Conclusions With stringently adopted Rome III and DSM-IV-TR criteria, dyspepsia was strongly associated and often coincident in onset with generalised anxiety disorder and major depressive episodes in the community. Excessive healthcare utilisation should alert clinicians to risk of psychiatric comorbidity.
著者Mak ADP, Wu JCY, Chan Y, Chan FKL, Sung JJY, Lee S
期刊名稱Alimentary Pharmacology and Therapeutics
頁次800 - 810
Web of Science 學科類別Gastroenterology & Hepatology; GASTROENTEROLOGY & HEPATOLOGY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

上次更新時間 2020-23-10 於 01:36