ULTRASOUND FINDINGS OF PAPILLARY THYROID MICROCARCINOMA: A REVIEW OF 113 CONSECUTIVE CASES WITH HISTOPATHOLOGIC CORRELATION
Publication in refereed journal

香港中文大學研究人員

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摘要Papillary thyroid microcarcinoma (PTMC) is a malignant thyroid tumor of less than 1 cm in size. Ultrasound (US) is the preferred imaging modality for PTMC. This study retrospectively evaluated the US results from 113 consecutive cases of PTMC with 127 nodules and correlated the results with the histopathologic findings. The results showed none of the PTMC nodules had a cystic element. Half of the PTMC nodules had a well-defined boundary and the remaining half had an ill-defined boundary. A percent (6.3%) of the nodules had a halo sign. Microcalcification was present in approximately half of the PTMC nodules. The cancerous tissue with a papillary structure was hypoechogenic and the amount of fibrous stroma determined whether the nodule echogenicity was heterogeneous or homogeneous. Heterogeneous echogenicity was associated with a fibrous stroma proportion of >20%. Only PTMC nodules with predominantly follicular structures containing a large proportion of colloid demonstrated isoechogenicity. Well-defined boundaries on US were associated with well-defined histologic margins, with or without the presence of an intact fibrous pseudo-capsule. A halo sign with a well-defined boundary detected by US was associated with the presence of an intact fibrous pseudo-capsule. Half of the PTMC nodules with ill-defined boundaries exhibited infiltration into the surrounding thyroid tissue, while the remaining half of the PTMC nodules with ill-defined boundaries on US presented irregular nodule margins by histology, rather than nodule infiltration. Psammoma bodies detected at a frequency >= 5 per x200 microscopic field of view were detectable on US as microcalcifications. (E-mail: zhouchunwu@hotmail.com) (c) 2012 World Federation for Ultrasound in Medicine & Biology.
著者Wang Y, Li L, Wang YXJ, Feng XL, Zhao F, Zou SM, Hao YZ, Ying JM, Zhou CW
期刊名稱Ultrasound in Medicine and Biology
出版年份2012
月份10
日期1
卷號38
期次10
出版社ELSEVIER SCIENCE INC
頁次1681 - 1688
國際標準期刊號0301-5629
電子國際標準期刊號1879-291X
語言英式英語
關鍵詞Boundary; Cystic degeneration; Echogenicity; Halo sign; Microcalcification; Papillary thyroid microcarcinoma; Psammoma body; Ultrasound
Web of Science 學科類別Acoustics; ACOUSTICS; Radiology, Nuclear Medicine & Medical Imaging; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

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