The pathological roles of BART miRNAs in nasopharyngeal carcinoma
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AbstractNasopharyngeal carcinoma (NPC) is a distinct type of head and neck cancer prevalent in south-east Asia and southern China, where it constitutes a significant health burden. Although the close association of NPC with EpsteinBarr virus (EBV) infection has been known for more than four decades, the exact role that EBV plays in the pathogenesis of this malignancy is still unclear. While NPC tumours are known to express a number of EBV-encoded proteins, they also express a large number of virus-encoded microRNAs (miRNAs), the most abundant of which are those encoded from the BamHI-A region of the viral genome: the so-called BART miRNAs. miRNAs are small non-coding mRNAs that negatively regulate the expression of various genes at the post-transcriptional level. Accumulating evidence suggests that miRNAs play important roles in tumourigenesis. Here, we review the role of EBV-encoded BART miRNAs in modulating apoptosis and host innate defence mechanisms and their contribution to NPC pathogenesis. The rationale and strategies for therapeutic targeting of BART miRNAs in EBV-infected NPC are also discussed. Copyright (C) 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
All Author(s) ListLo AKF, Dawson CW, Jin DY, Lo KW
Journal nameJournal of Pathology
Year2012
Month8
Day1
Volume Number227
Issue Number4
PublisherWILEY-BLACKWELL
Pages392 - 403
ISSN0022-3417
eISSN1096-9896
LanguagesEnglish-United Kingdom
KeywordsBART; Epstein-Barr virus; miRNA; nasopharyngeal carcinoma
Web of Science Subject CategoriesOncology; ONCOLOGY; Pathology; PATHOLOGY

Last updated on 2020-20-09 at 02:49