Simultaneously Improving the Mechanical Properties, Dissolution Performance, and Hygroscopicity of Ibuprofen and Flurbiprofen by Cocrystallization with Nicotinamide
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AbstractTo be fully exploitable in both formulation and manufacturing, a drug cocrystal needs to demonstrate simultaneous improvement of multiple key pharmaceutical properties over the pure drug crystal. The present work was aimed at investigating such feasibility with two model profen-nicotinamide cocrystals.
All Author(s) ListChow SF, Chen M, Shi LM, Chow AHL, Sun CC
Journal namePharmaceutical Research
Year2012
Month7
Day1
Volume Number29
Issue Number7
PublisherSPRINGER/PLENUM PUBLISHERS
Pages1854 - 1865
ISSN0724-8741
eISSN1573-904X
LanguagesEnglish-United Kingdom
Keywordscrystal engineering; dissolution; pharmaceutical cocrystal; solubility; tabletability
Web of Science Subject CategoriesChemistry; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-23-10 at 01:35