Attribution of human papillomavirus types to cervical intraepithelial neoplasia and invasive cancers in southern China
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摘要The attribution of individual human papillomavirus (HPV) types to cervical neoplasia, especially intraepithelial lesions, varies ethnogeographically. Population-specific data are required for vaccine cost-effectiveness assessment and type replacement monitoring. HPV was detected from 2,790 Chinese women (444 invasive cervical cancers [ICC], 772 cervical intraepithelial neoplasia [CIN] grade 3, 805 CIN2 and 769 CIN1. The attribution of each HPV type found in multiple-type infections was approximated by the fractional contribution approach. Multiple-type infection was common and correlated inversely with lesion severity (54.7% for CIN1, 48.7% for CIN2, 46.2% for CIN3, 27.5% for ICC). Vaccine-covered high-risk types (HPV16/18) attributed to 59.5% of squamous cell carcinoma, 78.6% of adenocarcinoma, 35.9% of CIN3, 18.4% of CIN2 and 7.4% of CIN1. Distinct features compared to worldwide were a higher attribution of HPV52 and HPV58, and a much lower attribution of HPV45. Inclusion of HPV52 and HPV58 in future vaccines would provide the highest marginal increase in coverage with 11.7% for squamous cell carcinoma, 14.4% for CIN3, 22.6% for CIN2 and 17.7% for CIN1. The attribution of HPV types in southern China is different from elsewhere, which should be considered in prioritizing HPV types for vaccine and screening assay development.
著者Chan PKS, Cheung TH, Li WH, Yu MY, Chan MYM, Yim SF, Ho WCS, Yeung ACM, Ho KM, Ng HK
期刊名稱International Journal of Cancer
出版年份2012
月份8
日期1
卷號131
期次3
出版社WILEY-BLACKWELL
頁次692 - 705
國際標準期刊號0020-7136
電子國際標準期刊號1097-0215
語言英式英語
關鍵詞Chinese; Hong Kong; prevalence; type replacement; vaccine
Web of Science 學科類別Oncology; ONCOLOGY

上次更新時間 2020-26-10 於 00:21