Thrombophilia among Chinese Women with Venous Thromboembolism during Pregnancy
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摘要Aims: To assess the prevalence of thrombophilia among Chinese women with venous thromboembolism (VTE) developed during pregnancy. Methods: Based on information from a tertiary teaching unit, all recorded cases of deep vein thrombosis (DVT) and pulmonary embolism (PE) during pregnancy diagnosed between 1997 and 2005, were assessed for prevalence of thrombophilia. Fifty-five healthy women, who had at least one normal pregnancy but without any previous history of VTE, were recruited as controls. Results: A total of 44 subjects completed thrombophilia screening, of whom 5 (11%) were confirmed to have thrombophilia [protein C (PC) deficiency (2), protein S (PS) deficiency (1), combined PC & PS deficiency (1) and antithrombin III deficiency (1)]. Homozygous 5,10-methylenetetrahydrofolate reductase (C677T) gene mutation was found in 6 (14%) subjects but not in the controls. There was no antiphospholipid syndrome, activated PC resistance, factor V Leiden or prothrombin gene mutations. Conclusion: In the Chinese population, PS and PC deficiencies are common thrombophilia for VTE during pregnancy and thrombophilia screening should be recommended in all pregnant women who suffer from VTE. Copyright (C) 2012 S. Karger AG, Basel
著者Tam WH, Ng MHL, Yiu AKW, Lau KM, Cheng GYM, Li CY
期刊名稱Gynecologic and Obstetric Investigation
出版年份2012
月份1
日期1
卷號73
期次3
出版社KARGER
頁次183 - 188
國際標準期刊號0378-7346
電子國際標準期刊號1423-002X
語言英式英語
關鍵詞Chinese; Pregnancy; Thrombophilia
Web of Science 學科類別Obstetrics & Gynecology; OBSTETRICS & GYNECOLOGY

上次更新時間 2020-20-09 於 02:48