Thrombophilia among Chinese Women with Venous Thromboembolism during Pregnancy
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AbstractAims: To assess the prevalence of thrombophilia among Chinese women with venous thromboembolism (VTE) developed during pregnancy. Methods: Based on information from a tertiary teaching unit, all recorded cases of deep vein thrombosis (DVT) and pulmonary embolism (PE) during pregnancy diagnosed between 1997 and 2005, were assessed for prevalence of thrombophilia. Fifty-five healthy women, who had at least one normal pregnancy but without any previous history of VTE, were recruited as controls. Results: A total of 44 subjects completed thrombophilia screening, of whom 5 (11%) were confirmed to have thrombophilia [protein C (PC) deficiency (2), protein S (PS) deficiency (1), combined PC & PS deficiency (1) and antithrombin III deficiency (1)]. Homozygous 5,10-methylenetetrahydrofolate reductase (C677T) gene mutation was found in 6 (14%) subjects but not in the controls. There was no antiphospholipid syndrome, activated PC resistance, factor V Leiden or prothrombin gene mutations. Conclusion: In the Chinese population, PS and PC deficiencies are common thrombophilia for VTE during pregnancy and thrombophilia screening should be recommended in all pregnant women who suffer from VTE. Copyright (C) 2012 S. Karger AG, Basel
All Author(s) ListTam WH, Ng MHL, Yiu AKW, Lau KM, Cheng GYM, Li CY
Journal nameGynecologic and Obstetric Investigation
Volume Number73
Issue Number3
Pages183 - 188
LanguagesEnglish-United Kingdom
KeywordsChinese; Pregnancy; Thrombophilia
Web of Science Subject CategoriesObstetrics & Gynecology; OBSTETRICS & GYNECOLOGY

Last updated on 2020-20-09 at 02:48