Photocytotoxicity and Magnetic Relaxivity Responses of Dual-Porous γ-Fe2O3@meso-SiO2 Microspheres
Publication in refereed journal

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摘要Novel high magnetization microspheres with porous γ-Fe2O3 core and porous SiO2 shell were synthesized using a templating method, whereas the size of the magnetic core and the thickness of the porous shell can be controlled by tuning the experimental parameters. By way of an example, as-prepared γ-Fe2O3@meso-SiO2 microspheres (170 nm) display excellent water-dispersity and show photonic characteristics under externally applied a magnetic field. The magnetic property of the γ-Fe2O3 porous core enables the microspheres to be used as a contrast agent in magnetic resonance imaging with a high r2 (76.5 s–1 mM–1 Fe) relaxivity. The biocompatible composites possess a large BET surface area (222.3 m2/g), demonstrating that they can be used as a bifunctional agent for both MRI and drug carrier. Because of the high substrate loading of the magnetic, dual-porous materials, only a low dosage of the substrate will be acquired for potential practical applications. Hydrophobic zinc(II) phthalocyanine (ZnPC) photosensitizing molecules have been encapsulated into the dual-porous microspheres to form γ-Fe2O3@meso-SiO2–ZnPC microspheres. Biosafety, cellular uptake in HT29 cells, and in vitro MRI of these nanoparticles have been demonstrated. Photocytotoxicity (λ > 610 nm) of the HT29 cells uptaken with γ-Fe2O3@meso-SiO2–ZnPC microspheres has been demonstrated for 20 min illumination.
著者Xuan SH, Lee SF, Lau JTF, Zhu XM, Wang YXJ, Wang F, Lai JMY, Sham KWY, Lo PC, Yu JC, Cheng CHK, Leung KCF
期刊名稱ACS Applied Materials and Interfaces
出版年份2012
月份4
卷號4
期次4
出版社AMER CHEMICAL SOC
頁次2033 - 2040
國際標準期刊號1944-8244
電子國際標準期刊號1944-8252
語言英式英語
關鍵詞drug carrier, magnetic resonance imaging, nanoparticle, photocytotoxicity, porosity
Web of Science 學科類別Materials Science; Materials Science, Multidisciplinary; MATERIALS SCIENCE, MULTIDISCIPLINARY; Nanoscience & Nanotechnology; NANOSCIENCE & NANOTECHNOLOGY; Science & Technology - Other Topics

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